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phenobarbital will lessen the extent or result of disopyramide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.phenobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration with strong CYP3A4 inducers; these medicat